The Dreaden Lab

Molecular Engineering for Tumor Immunity

Publications

 †first author, *corresponding author

  1. Summers R, Jain J, Vasileiadi E, Smith B, Chimenti ML, Yeung TY, Kelvin J, Wang X, Frye SV, Earp HS, Tyner JW, Dreaden EC, DeRyckere D, Graham DK, Therapeutic Targeting of MERTK and BCL-2 in T-Cell and Early T-Precursor Acute Lymphoblastic Leukemia. Cancers, 14:24, 6142.
  2. Birnbaum LA, Sullivan E, Do P, Uricoli B, Porter CC, Henry CJ, Dreaden EC,* Multicolor Light-Induced Immune Activation via Polymer Photocaged Cytokines, bioRxiv, 2022, 2022.10.03.510638.
  3. Kelvin JM, Zhang DY, Williams EK, Moore SG, Birnbaum LA, Zecca H, Wang X, Jain J, Qui M, Jui NT, Fu H, Du Y, Kemp ML, Lam WA, DeRyckere D, Graham DK, Dreaden EC,* Screening and Development of Constitutively Synergistic Combination Drug Formulations for T Cell Acute Lymphoblastic Leukemia. bioRxiv, 2022: 2022.2009.2021.508196.
  4. Kong YW, Dreaden EC,* PEG: Will it come back to you? Polyethelyne glycol immunogenicity, COVID vaccines, and the case for new PEG alternatives. Frontiers in Bioengineering and Biotechnology, 2022, 10: 879988.
  5. Hunter R, Imbach K, Dougan J, Do P, Townsel A, Zhou C, Gibson G, Dreaden EC, Haynes K, Henry CJm Porter CC, B-cell acute lymphoblastic leukemia promotes an immune suppressive microenvironment that can be overcome by IL-12. Scientific Reports, 2022, 12: 1-13.
  6. Uricoli B, Birnbaum LA, Do P, Kelvin JM, Jain J, Costanza E, Chyong A, Porter CC, Rafiq S, Dreaden EC,* Engineered Cytokines for Cancer and Autoimmune Disease Therapy, Advanced Healthcare Materials, 2021, 2002214.
  7. Do P, Perdue LA, Chyong A, Hunter R, Dougan J, Henry CJ, Porter CC,* Dreaden EC,* Rapid Assembly and Screening of Multivalent Immune Cell-Redirecting Therapies for Leukemia. ACS Combinatorial Science, 2020: 22: 533-541.
  8. Perdue, LA, Do, P, David, C, Chyong, A, Kellner, AV, Ruggieri, A, Kim, HR, Salaita, K, Lesinski, GB, Porter, CC, Dreaden, EC,* Optical Control of Cytokine Signaling via Bioinspired, Polymer-Induced Latency. Biomacromolecules, 2020: 21: 2635-2644.
  9. Kong YW,† Dreaden EC,† Morandell S, Zhou W, Dhara SS, Sriram G, Lam FC, Patterson JC, Quadir M, Dinh A, Shopsowitz KE, Varmeh S, Yilmaz ÖH, Lippard SJ, Reinhardt HC, Hemann MT, Hammond PT, Yaffe MB, Enhancing chemotherapy response through augmented synthetic lethality by co-targeting nucleotide excision repair and cell-cycle checkpoints. Nature Communications, 2020 11: 4124.
  10. Silva AS, Shopsowitz KE, Correa S, Morton SW, Dreaden EC, Casimiro T, Aguiar-Ricardo A, Hammond PT, Rational Design of Multistage Drug Delivery Vehicles for Pulmonary RNA Interference Therapy. Int. J. Pharm., 2020: 119989.
  11. Correa, S.; Boehnke, N.; Barberio, A.E.; Deiss-Yehiely E.; Shi, A.; Oberlton, B.; Smith, S.G.; Zervantonakis, I.A.; Dreaden, E.C.; Hammond, P.T.; Tuning Nanoparticle Interactions with Ovarian Cancer through Layer by Layer Modification of Surface Chemistry, ACS Nano, 2020, 14 (2), 2224-2237.
  12. Choi, K.Y.; Correa, S.; Min, J.; Li, J.; Roy, S.; Laccetti, K.H.; Dreaden, E.C.; Kong, S.; Roun, H.; Roh, Y.H.; Lawson, E.C.; Palmer, P.A.; Hammond, P.T.; Binary Targeting of siRNA to Hematologic Cancer Cells In Vivo using Layer-by-Layer Nanoparticles, Advanced Functional Materials, 2019, 29 (20), 1900018. PMCID: PMC6910249
  13. Dreaden, E.C.;† Kong, Y.W.;† Quadir, M.A.; Correa, S.; Suárez-López, L.; Barberio, A.E.; Hwang, M.K.; Shi, A.C.; Olberton, B.J.; Gallagher, P.N.; Shopsowitz, K.E.; Elias, K.M.; Yaffe, M.B.; Hammond, P.T., RNA-Peptide nanoplexes drug DNA damage pathways in high-grade serous ovarian tumors, Bioengineering and Translational Medicine, 2018, 3, 26-36.
  14. Saei, A.A.; Yazdani, M.; Lohse, S.E.; Bakhtiary, Z.; Serpooshan, V.; Ghavami, M.; Asadian, M.; Mashaghi, S.; Dreaden, E.C.; Mashaghi, A.; Mahmoudi; M., Nanoparticle Surface Functionality Dictates Cellular and Systemic Toxicity, Chemistry of Materials, 2017, 29 (16), 6578-6595.
  15. Behzadi, S.; Serpooshan, V.; Tao, W.; Hamaly, M.A.; Alkawareek, M.Y.; Dreaden, E.C.; Brown, D.; Alkilany, A.M.; Farokhzad, O.C.; Mahmoudi, M., Cellular uptake of nanoparticles: journey inside the cell, Chemical Society Reviews, 2017, 46, 4218-4244.
  16. Correa, S;† Dreaden, E.C.;† Gu, L.; Hammond, P.T., Engineering Nanolayered Particles for Modular Drug Delivery, Journal of Controlled Release, 2016, 240, 364–386.
  17. Min, J.; Choi; K.Y.; Dreaden, E.C.; Padera, R.F.; Braatz, R.D.; Spector, M.; Hammond, P.T., Designer Dual Therapy Nanolayered Implant Coatings Eradicate Biofilms and Accelerate Bone Tissue Repair, ACS Nano, 2016, 10(4), 4441–4450.
  18. Shopsowitz, K.E.; Wu, C.; Liu, G.; Dreaden, E.C.; Hammond, P.T., Periodic-shRNA Molecules are Capable of Gene Silencing, Cytotoxicity and Innate Immune Activation in Cancer Cells, Nucleic Acid Research, 2016, 44 (2), 545-557. PMCID: PMC4737167
  19. Kong, Y.W.;† Dreaden, E.C.;† Hammond, P.T.; Yaffe, M.B., Exploiting Nanocarriers for Combination Cancer Therapy. In Intracellular Delivery III; 1st Ed. Prokop, A.; Weissig, V., Eds.; Springer International: Switzerland, 2016. ISBN: 978-3-319-43525-1.
  20. Roh, Y.H; Deng, J.Z.; Dreaden, E.C.; Park, J.H.; Yun, D.S.; Shopsowitz, K.E.; Hammond, P.T., A Multi-RNAi Microsponge Platform for Simultaneous Controlled Delivery of Multiple Small Interfering RNAs, Angewandte Chemie International Edition, 2016, 55, 3347–3351. PMCID: PMC4768639
  21. Correa, S; Choi; K.Y.; Dreaden, E.C.; Renggli, K.; Shi, A.; Gu, L.; Shopsowitz, K.E.; Quadir, M.; Ben-Akiva, E.; Hammond, P.T., Highly scalable, closed-loop synthesis of drug-loaded, layer-by-layer nanoparticles, Advanced Functional Materials, 2016, 26, 991–1003. PMCID: PMC4847955
  22. Dreaden, E.C.; Kong, Y.W.; Morton, S.W.; Correa, S.; Choi; K.Y.; Shopsowitz, K.E.; Renggli, K.; Drapkin, R.; Yaffe; M.B.; Hammond, P.T., Tumor-Targeted Synergistic Blockade of MAPK and PI3K from a Layer-by-Layer Nanoparticle, Clinical Cancer Research, 2015, 21(19), 4410-4419. PMCID: PMC4624301
  23. Choi, J.H.; Kim, S.-O.; Linardy, E.; Dreaden, E.C.; Zhdanov, V.P.; Hammond, P.T.; Cho, N.-J., Influence of pH and Surface Chemistry on Poly-L-Lysine Adsorption onto Solid Supports Investigated by Quartz Crystal Microbalance with Dissipation Monitoring, Journal of Physical Chemistry B, 2015, 119(33), 10554–10565.
  24. Choi, J.H.; Kim, S.-O.; Linardy, E.; Dreaden, E.C.; Zhdanov, V.P.; Hammond, P.T.; Cho, N.-J., Adsorption of Hyaluronic Acid on Solid Supports: Role of pH and Surface Chemistry in Thin Film Self-Assembly, 2015, Journal of Colloid & Interface Science, 2015, 448, 197-207.
  25. Dreaden, E.C., Morton, S.W.; Shopsowitz, K.E., Choi, J.H.; Deng, Z.J.; Cho, N.-J.; Hammond, P.T., Bimodal Tumor-Targeting From Microenvironment Responsive Hyaluronan Layer-by-Layer (LbL) Nanoparticles. ACS Nano, 2014, 8 (8), 8374-8382. PMCID: PMC4148172
  26. Sowers, M.A.; McCombs, J.R.; Wang, Y.; Paletta, J.T.; Morton, S.W.; Dreaden, E.C.; Boska, M.; Ottaviani, F.; Hammond, P.T.; Rajca, A.; Jeremiah, J.A., Redox responsive branched-bottlebrush polymers for in vivo MRI and fluorescence imaging. Nature Communications, 2014, 5, 5460. PMCID: PMC4269368
  27. Roh, Y.H.; Lee, J.B.; Shopsowitz, K.E.; Dreaden, E.C.; Morton, S.W.; Poon, Z.; Hong, J.; Yamin, I.; Bonner, D.K.; Hammond, P.T., Layer-by-Layer Assembled Anti-Sense DNA Microsponge Particles for Efficient Delivery of Cancer Therapeutics. ACS Nano, 2014, 8(10), 9767-9780. PMCID: PMC4148172
  28. Shah, N.J.; Hsu, B.B.; Dreaden, E.C.; Hammond, P.T., Engineering Layer-by-Layer Thin Films for Multiscale and Multidrug Delivery Applications. In Layer-by-Layer Films for Biomedical Applications; 1st Ed. Picart, C.; Caruso, F., Voegel, J.-C., Eds.; Wiley-VCH: Weinheim, 2014. ISBN: 978-3-527-33589-3.
  29. Dreaden, E.C.; El-Sayed, I.H.; El-Sayed, M.A. Structure-Activity Relationships For Tumor-Targeting Gold nanoparticles. In Frontiers of Nanobiomedical Research; 1st Ed. Torchilin, V.P., Ed.; World Scientific: Hackensack, NJ, 2014. ISBN: 978-981-4520-64-5.
  30. Morton, S.W.; Lee, M.J.; Deng, Z.J.; Dreaden, E.C.; Siouve, E.; Shopsowitz, K.E.; Shah, N.J.; Yaffe, M.B., Hammond, P.T. A Nanoparticle-Based Combination Chemotherapy Delivery System for Enhanced Tumor Killing by Dynamic Rewiring of Signaling Pathways. Science Signaling, 2014, 7 (325), ra44. PMCID: PMC4138219
  31. Austin, L.A.; Mackey, M.A.; Dreaden, E.C.; El-Sayed, M.A.; The optical, photothermal, and facile surface chemical properties of gold and silver nanoparticles in biodiagnostics, therapy, and drug delivery. Archives in Toxicology, 2014, 88 (7), 1391-417. PMCID: PMC4136654
  32. Liao, L.; Liu, J.; Dreaden, E.C.; Morton, S.; Shopsowitz, K.E.; Hammond, P.T.; Johnson, J.A., A convergent synthetic platform for single-nanoparticle triplex combination cancer therapy: ratiometric loading and release of cisplatin, doxorubicin, and camptothecin. Journal of the American Chemical Society, 2014, 136 (16), 5896–5899. PMCID: PMC4105175
  33. Dreaden, E.C.; Raji, I.O.; Austin, L.A.; Fathi, S.; Mwakwari, S.C.; Humphries IV, W.H.; Kang, B.; Oyelere, A.K.; El-Sayed, M.A. P-glycoprotein-Dependent Trafficking of Nanoparticle-Drug Conjugates. Small, 2014, 10 (9), 1719–1723. PMCID: PMC4136971
  34. Deng, Z.J.; Morton, S.W.; Ben-Akiva, E.; Dreaden, E.C.; Shopsowitz, K.E.; Hammond, P.T., Layer-by-Layer Nanoparticles for Systemic Codelivery of an Anticancer Drug and siRNA for Potential Triple-Negative Breast Cancer Treatment. ACS Nano, 2013, 7 (11), 9571–9584. PMCID: PMC3870477
  35. Dreaden, E.C.; Gryder, B.G.; Austin, L.A.; Tene Defo, B.A.; Hayden, S.C.; Pi, M.; Quarles, L.D.; Oyelere, A.K.; El-Sayed, M.A., Antiandrogen Gold Nanoparticles Dual-Target and Overcome Treatment Resistance in Hormone-Insensitive Prostate Cancer Cells. Bioconjugate Chemistry, 2012, 23 (8), 1507-1512. PMCID: PMC3434689
  36. Dreaden, E.C.; Mwakwari, S.C.; Austin, L.A.; Kieffer, M.J.; Oyelere, A.K.; El-Sayed, M.A. Small Molecule-Gold Nanorod Conjugates Selectively Target and Induce Macrophage Cytotoxicity Towards Breast Cancer Cells. Small, 2012, 8 (18), 2819-2822. PMCID: PMC3459581
  37. Dreaden, E.C.; El-Sayed, M.A.; Detecting and Destroying Cancer Cells in More than One Way with Noble Metals and Different Confinement Properties on the Nanoscale. Accounts of Chemical Research, 2012, 45 (11), 1854–1865.
  38. Dreaden, E.C.; Austin, L.A.; Mackey, M.A.; El-Sayed, M.A.; Size Matters: Gold Nanoparticles in Targeted Cancer Drug Delivery. Therapeutic Delivery, 2012, 3, 457-478. PMCID: PMC3596176
  39. Dreaden, E.C.; Alkilany, A.; Huang, X.; Murphy, C.J.; El-Sayed, M.A. The Golden Age: Gold Nanoparticles for Biomedicine. Chemical Society Reviews, 2012, 41, 2740-2779. PMC Journal – In Process
  40. Dreaden, E.C.; Near, R.D.; Abdallah, T.; Talaat, M.H.; El-Sayed, M.A., Multimodal Plasmon Coupling in Low Symmetry Gold Nanoparticle Pairs Detected in Surface-Enhanced Raman Scattering (SERS). Applied Physics Letters, 2011, 98, 183115.
  41. Dreaden, E.C.; El-Sayed, M.A.; El-Sayed, I.H., Nanotechnology and Nanostructures Applied in Head and Neck Cancer. In Nanomedicine and Cancer; 1st Ed. Preedy, V.R., Srirajaskanthan, R., Eds.; Nanoscience Applied to Health and Medicine Series; Science Publishers: Enfield, NH, 2011, 373-395; ISBN 978-1-57808-727-3.
  42. Yen, C.-W.; Hayden, S.C.; Dreaden, E.C.; Szymanski, P.; El-Sayed, M.A., Tailoring Plasmonic and Electrostatic Field Effects to Maximize Solar Energy Conversion by Bacteriorhodopsin, the Other Natural Photosynthetic System. Nano Letters, 2011, 11 (9), 3821–3826.
  43. Dreaden, E.C.; Mackey, M.A.; Huang, X.; Kang, B.; El-Sayed, M.A., Beating Cancer in Multiple Ways Using Nanogold. Chemical Society Reviews, 2011, 40 (7), 3391–3404. PMC Journal – In Process
  44. Dreaden, E.C.; Neretina, S.; Qian, W.; Hughes, R.A.; Preston, J.S.; Mascher, P; El-Sayed, M.A., Plasmonic Enhancement of Nonradiative Charge Carrier Relaxation and Proposed Effects from Enhanced Radiative Electronic Processes in Semiconductor-Gold Core-Shell Nanorod Arrays. Journal of Physical Chemistry C, 2011, 115, 5578–5583.
  45. Dreaden, E.C.; Mwakwari, S. C.; Sodji, Q. H.; Oyelere, A. K.; El-Sayed, M. A., Tamoxifen-Poly(ethylene glycol)-Thiol Gold Nanoparticle Conjugates: Enhanced Potency and Selective Delivery for Breast Cancer Treatment. Bioconjugate Chemistry, 2009, 20, 2247–2253. PMCID: PMC2839930
  46. Neretina,S.; Dreaden,E.C.; Qian,W.; Hughes,R.A.; Preston,J.S.; Mascher, P.; El-Sayed, M.A., The Dependence of the Plasmon Field Induced Nonradiative Electronic Relaxation Mechanisms on the Gold Shell Thickness in Vertically Aligned CdTe−Au Core−Shell Nanorods. Nano Letters, 2009, 9 (11), 3772–3779.
  47. Neretina, S.; Qian, W.; Dreaden, E.C.; El-Sayed, M. A.; Hughes, R. A.; Preston, J. S.; Mascher, P., Exciton Lifetime Tuning by Changing the Plasmon Field Orientation with Respect to the Exciton Transition Moment Direction: CdTe-Au Core-Shell Nanorods. Nano Letters, 2009, 9 (3), 1242-1248.
  48. Dickerson, E. B.;† Dreaden, E.C.;† Huang, X.; El-Sayed, I. H.; Chu, H.; Pushpanketh, S.; McDonald, J. F.; El-Sayed, M. A., Gold nanorod assisted near-infrared plasmonic photothermal therapy (PPTT) of squamous cell carcinoma in mice. Cancer Letters, 2008, 269 (1), 57-66. PMCID: PMC3413727
  49. Neretina, S.; Qian, W.; Dreaden, E.C.; El-Sayed, M. A.; Hughes, R. A.; Preston, J. S.; Mascher, P., Plasmon field effects on the nonradiative relaxation of hot electrons in an electronically quantized system: CdTe-Au core-shell nanowires. Nano Letters, 2008, 8 (8), 2410-2418.